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加米霉素對豬呼吸道常見病原菌的體外抗菌活性研究

時間:2019-06-26 20:10來源:畢業論文
以加米霉素為研究對象,采用微量肉湯稀釋法測定其對豬呼吸道常見致病細菌的最小抑菌濃度。同時,通過與對照藥物替米考星相比較,進一步佐證其抑菌效果,從而為臨床合理應用加

摘要:豬呼吸道疾病是由細菌、病毒或寄生蟲單獨和/或混合感染引起的豬肺炎、支氣管炎等疾病的通稱,是一種世界范圍內危害養豬業健康發展的重要疾病。該病病因復雜,病原眾多,易受到轉群運輸、極端天氣、室內溫濕度、飼養密度、代謝紊亂、免疫低下等因素影響,具有發病率高、死亡率高、飼料報酬率低和經濟損失嚴重等特點。若治療不及時,將影響豬的生長發育,導致飼料利用率低,甚至死亡,給豬場帶來嚴重損失。針對該病,目前國內外尚缺乏有效的疫苗預防,仍主要依靠抗菌藥物防治。本文以加米霉素為研究對象,采用微量肉湯稀釋法測定其對豬呼吸道常見致病細菌的最小抑菌濃度。同時,通過與對照藥物替米考星相比較,進一步佐證其抑菌效果,從而為臨床合理應用加米霉素提供依據。36651
畢業論文關鍵詞:豬呼吸道疾病;加米霉素;最小抑菌濃度;微量肉湯稀釋法
In vitro antibacterial activity of common pathogens isolated from porcine respiratory tract of Gamithromycin
Abstract:Porcine respiratory disease is caused by bacteria, viruses or parasites alone and / or mixed infection caused by porcine pneumonia, bronchitis and other diseases known as a worldwide threat to the healthy development of the pig industry, an important disease. The cause of the disease complex, many pathogens. It is easy to be influenced by such factors as trans - group transportation, extreme weather, indoor temperature and humidity, feeding density, metabolic disorder, immunocompromised and so on. It has the characteristics of high morbidity, high mortality, low feed rate and serious economic losses. If the treatment is not timely, it will affect the growth and development of pigs, leading to low utilization of feed and even death, which will cause serious losses to the pig farms. In view of this disease, there is still a lack of effective vaccine prevention at home and abroad, and it still relies mainly on the prevention and control of antimicrobial agents. This paper intends to use the Gamithromycin for the object, which is the novel semisynthesis macrolide for animals.Then,The minimum inhibitory concentration of common pathogenic bacteria in porcine respiratory tract was determined by microdilution broth dilution method.At the same time,compared with the control drug tilmicosin,further evidence of its antibacterial effect, so as to provide the basis for the clinical application of Gamithromycin.

源`自!六^維"論^文;網www.aftnzs.live


Key words: Porcine respiratory disease;Gamithromycin;Minimum inhibitory concentration;Microdilution broth dilution method;
目 錄
摘要    1
關鍵詞    1
Abstract    1
Key words    1
引言    1
1材料與方法    3
1.1材料    3
1.1.1 藥品    3
1.1.2 試驗菌株    3
1.1.3 培養基和試劑    3
1.1.4 主要儀器和設備    3
1.1.5 試驗時間地點    4
1.2 試驗方法    4
1.2.1 藥品儲備液的制備    4
1.2.2 菌液的制備    4
1.2.3 藥敏試驗的操作    4
1.2.4 藥敏試驗質控    4
1.2.5 結果判定    4
1.3 數據處理    5
2結果與分析    5
3小結    9
致謝    9
參考文獻    9
加米霉素對呼吸道常見病原菌的體外抗菌活性研究引言 
豬呼吸道疾病是目前我國規模化豬場的常發病、多發病,一年四季均有發生,尤其是在每年的春、秋季節,由于氣溫驟變、豬舍潮濕、通風不良、豬群飼養密度過大時最易發生該病,有的豬場發病率高達40%~80%,其中直接死亡率可達20%[1]。其危害性極大,不但造成豬的直接死亡,而且豬群增重緩慢,出欄延遲,已成為養豬疫病防治中最突出和難控制的問題[2]。若防治與治療不到位,很容易給養豬業造成重大損失[3]。 加米霉素對豬呼吸道常見病原菌的體外抗菌活性研究:http://www.aftnzs.live/yixue/20190626/35209.html
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