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新型NCN型配體的合成及其表征

時間:2019-06-02 14:49來源:畢業論文
闡述了合成的幾種噁唑啉類配體,包括單噁唑啉配體和雙噁唑啉配體,并將該類配體主要運用于了催化不對稱反應,比如Diels-Alder反應和環丙烷化反應等的研究中,并最終對這類配體進行

摘要:催化不對稱合成已成為有機合成和金屬有機合成的前沿領域,其中不對稱反應是合成的關鍵。我們知道,催化劑是一種產生不對稱的感應和控制手性配體的來源,我們應該如何設計催化劑高選擇性催化性能強的是在不對稱催化合成中的關鍵。含氮配體擁有來源易得、性質穩定等許多優點,而且還能夠與過渡金屬形成比較好的配合物,從而進一步高效的催化反應,因此在如此多的手性配體中,含氮配體是一類非常重要的手性配體。其中手性雙噁唑啉的制備主要是由手性氨基醇的酰胺化、鹵化、堿性關環而來。噁唑啉是同時含有氮和氧兩種原子的五元雜環化合物,由于氮原子能夠與金屬原子形成很穩定的配合物,因此噁唑啉比較容易與過渡金屬離子絡合,由此形成的催化劑具有良好的手性環境。噁唑啉衍生物是一類五元含氮雜環化合物,目前,已合成的手性噁唑啉配體的結構類型繁多。這篇論文主要是闡述了合成的幾種噁唑啉類配體,包括單噁唑啉配體和雙噁唑啉配體,并將該類配體主要運用于了催化不對稱反應,比如Diels-Alder反應和環丙烷化反應等的研究中,并最終對這類配體進行了表征。35931
畢業論文關鍵字:不對稱催化;手性噁唑啉配體;Diels-Alder 反應
Synthesis and characterization of new type NCN ligands
Abstract: Catalytic asymmetric synthesis has become the frontier of the organic and organometallic synthesis. The key of the synthesis is that asymmetric reaction. In the asymmetric catalytic synthesis, the key is that how to design the high selectivity and catalytic synthesis of  high performance catalyst, and the chiral ligands can lead to asymmetric induction and control of catalyst. Among numbers of chiral ligands, the nitrogen-containing ligand is an important one, with many advantages such as readily available and stability etc. They can be well formed as complexes with the transition metal to efficiently catalyze the reaction. The preparation of chiral Bisoxazoline comes mainly from the chiral amino alcohols amidation, halogenated alkaline ring. Bisoxazoline can easily complex with transition metal ions, forming a catalyst having good chiral environment. Oxazoline is a sort of five-membered heterocyclic compound containing N and O, and that the N atomic can also form stable complexes with the metal atoms. Oxazoline derivatives are a class of five-membered nitrogen-containing heterocyclic compounds, for the moment, there are a variety of structure of the synthesized chiral oxazoline ligands. In this thesis , several new chiral oxazoline ligands were synthesized , which is mainly used in catalytic asymmetric reaction of the study,( such as the Diels-Alder reaction, cyclopropanation reaction, henery reaction) , and were characterized by such ligands . 源¥自%六:維;論-文'網=www.aftnzs.live
Keywords: asymmetric catalysis;chiral oxazoline  ligands;Diels-Alder reaction
目 錄
1  引言    1
1.1 概述    1
1.2 噁唑啉的簡介    1
1.2.1 單噁唑啉    1
1.2.2 雙噁唑啉    2
1.2.3 多噁唑啉    2
1.3 噁唑啉衍生物的合成    2
1.3.1 以酰胺醇為前提的合成方法    3
1.3.2 以羧酸和β-氨基醇為前體的合成方法    6
1.3.3 以羧酸酯和β-氨基醇為前體的合成方法    7
1.3.4 以腈和β-氨基醇為前體的合成方法    7
1.3.5 以腈和環氧醇為前體合成    7
1.3.6 以異氰酸酯和乙醇胺為前體合成    8
1.3.7 以丙二酸亞胺脂和醛為前體【3+2】環加成法    8
1.3.8 以N-酰基噁唑烷酮為前體的合成    8
1.4 噁唑啉衍生物的應用    9 新型NCN型配體的合成及其表征:http://www.aftnzs.live/yixue/20190602/34150.html
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