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硫酸亞鐵微丸的制備+文獻綜述

時間:2019-05-24 21:50來源:畢業論文
以微晶纖維素和乳糖作為輔料,以聚吡咯烷酮K30作為粘合劑,采用流化床制粒法制備硫酸亞鐵微丸;考察相關的制備工藝,并對微丸的性能進行了考察,為進一步的研究提供數據支持

摘要:鐵缺乏是世界上最常見的營養疾病。硫酸亞鐵是一種生物利用率高且價格低廉的鐵營養強化劑, 但這種鐵鹽性質活潑, 容易氧化變色, 產生異味, 因此需要將其制備成便于服用的制劑。微丸是直徑小于1.5mm的球形或類球形顆粒制劑,它具有流動性好,易填裝膠囊,裝量差異小,釋藥穩定等特點。微丸在藥劑學領域中的應用十分廣泛,作為藥物的載體,它既可以進一步壓制成片劑,又可填充膠囊,不僅提高了藥物穩定性,而且可有效地調節藥物釋放速率。硫酸亞鐵微丸不僅可以作為一種口服制劑,而且可以直接加入食物中,以作為解決乳制品、面制品中鐵營養強化的一種有效途徑。本論文主要研究內容是以微晶纖維素和乳糖作為輔料,以聚吡咯烷酮K30作為粘合劑,采用流化床制粒法制備硫酸亞鐵微丸;考察相關的制備工藝,并對微丸的性能進行了考察,為進一步的研究提供數據支持。制備硫酸亞鐵微丸的最佳工藝條件為:進風溫度60℃、蠕動泵流速1.0~2.0mL/min、霧化壓力0.04~0.1 mpa、風機頻率為25Hz、粘合劑水溶液濃度30 g/mL;制得的硫酸亞鐵微丸流動性較好、藥物的均勻度良好,在粘合劑中加入抗氧化劑檸檬酸可顯著減少硫酸亞鐵的氧化。35677
畢業論文關鍵詞:工藝參數;物料參數;微丸;硫酸亞鐵
Preparation of ferrous sulfate pellets
Abstract: Iron deficiency is the most common nutritional disease in the world.. Ferrous sulfate is a biological utilization rate of high and low price of iron nutrition fortifier, but the iron nature lively, easy oxidation discoloration, produce peculiar smell. Therefore, it is necessary the prepared for taking the preparation. Micro pellets diameter less than 1.5 mm spherical or quasi spherical particles preparation. It has good fluidity, easy filling capsules, load small differences in release drug stability etc. characteristics. Pellets in the pharmacy field is widely used, as a drug carrier, it can further compressed into tablets, and capsule filling, not only improve the drug stability, and can effectively adjust the drug release rate. The iron pellets can be used as an oral preparation and can be added directly to food as an effective way to strengthen iron nutrition in milk and flour products. The main content of this thesis is with microcrystalline cellulose and lactose as accessories to pyrrolidone K30 as a binder, ferrous sulfate pellets were prepared by fluidized bed granulation; investigation related to the preparation process, and on the performance of the micro pill were investigated, to provide data support for the further research. Preparation of ferrous sulfate pellets of the optimum preparation process for: inlet air temperature is 60 DEG C, velocity of peristaltic pump 1.0~2.0mL/min, atomization pressure MPa 0.04~0.1, wind machine frequency of 25Hz, binder concentration was 30g/ml; preparation of ferrous sulfate micro pill liquidity better, drug good uniformity, in the adhesive added antioxidants citric acid can significantly reduce the oxidation of ferrous sulfate.
源¥自%六:維;論-文'網=www.aftnzs.live

Keywords: process parameters; material parameters; pellet; ferrous sulfate
 目錄
1 引言1
1.1 微丸的分類1
1.1.1 速釋微丸2
1.1.2 骨架型控釋微丸2
1.1.3 膜控型微丸3
1.1.4 膜控-骨架型微丸3
1.2 微丸的制備方法3
1.2.1 包衣鍋法制備微丸3
1.2.2 沸騰床制粒包衣法制備微丸3
1.2.3 流化床制粒法制備微丸3
1.2.4 液相法制備微丸4
1.2.5 震動噴嘴裝置法制備微丸4
1.2.6 擠出-滾圓法制備微丸4
1.2.7 熔融法制備微丸5
1.3 輔料的概述5
1.3.1 蠟質及不溶性阻滯劑5
1.3.2 熔融粘合劑5
1.3.3 薄膜材料5
1.3.4 增塑劑6
1.3.5 微晶纖維素6
1.3.6 乳糖6
1.4 鐵離子含量分析方法7
1.4.1鄰二氮雜菲法測定鐵含量7 硫酸亞鐵微丸的制備+文獻綜述:http://www.aftnzs.live/yixue/20190524/33726.html
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