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具有催淚活性的化合物的合成研究

時間:2019-06-23 21:07來源:畢業論文
以苯乙酮為測試底物,與毒性小、價格便宜的氯代試劑三氯異氰尿酸(TCCA)反應,并使用芐基三乙基氯化銨(TEBAC)作為催化劑,優化反應條件,嘗試發展綠色、高效的氯代化合物合成

摘要:傳統化學工業給環境帶來了的污染越來越嚴重,人們意識到了保護環境的重要性,由此人們提出了綠色化學的概念。最近幾年,大家越來越關注環境保護,所以實行綠色化學是非常有必要的。二氯代苯乙酮類化合物是重要的有機合成中間體,雖然現在有許多合成此類化合物的方法,但這些方法都存在著以下缺點:反應時間長、運用有毒的反應試劑、后處理麻煩等,這些都不符合綠色化學理念。因此,研究在無溶劑催化下完成無毒無害的快速反應是很有必要的。36579
本論文以苯乙酮為測試底物,與毒性小、價格便宜的氯代試劑三氯異氰尿酸(TCCA)反應,并使用芐基三乙基氯化銨(TEBAC)作為催化劑,優化反應條件,嘗試發展綠色、高效的氯代化合物合成路線。通過優化的實驗條件是:苯乙酮的量為1.20 g,三氯異氰尿酸的量為1.55 g,芐基三乙基氯化銨的用量為0.30 g,在室溫條件分3次加入下攪拌反應30 min,α,α-二氯代苯乙酮的產量為1.76 g,產率為92.1%。在優化條件的基礎上,將苯乙酮類化合物作為測試底物時發現,二氯代物的產率在73.2% ~ 93.5%之間,產率相對較高的是苯乙酮(92.1%),對甲基苯乙酮(93.5%)。
畢業論文關鍵詞: 二氯代苯乙酮;綠色化學;無溶劑反應
 The study of synthesis of lachrymatory compound
Abstract: Since the traditional chemical industry brings more and more serious the environment pollution, people realize the importance of protecting the environment. So people put forward the concept of green chemistry. In recent years, people are paying more and more attention to environmental protection, so it is necessary to carry out green chemistry. Chlorination of phenyl ethyl ketone compounds are important intermediates in organic synthesis, although there are many methods to synthesize these compounds, these methods have the following disadvantages, such as long reaction time,using toxic reaction reagent,post-processing of trouble and so on, which do not conform to the concept of green chemistry. Therefore, it is necessary to research done in solvent-free catalytic non-toxic harmless rapid response. 源`自!六^維"論^文;網www.aftnzs.live
This thesis is trying to optimize the reaction condition that using acetophenone as the substrate reacted with trichloroisocyanuric acid, which is cheap and low toxicity under using triethylbenzylammonium chloride as catalyst, then trying to develop the green and efficient synthetic route of chloride. The optimized experiment condition was: at the temperature, acetophenone, which  quality was 1.20 g and trichloroisocyanuric acid, which quality was 1.55 g were mixtured with triethylbenzylammonium chloride, which quality was 0.30 g, to stir for 30 min. Besides, triethylbenzylammonium chloride was pointed three times to join. The yield of α,α-dichloro phenylethanone was 92.1%. On the basis of the optimized conditions, when acetophenones were used as the substrate, the yield of chlorination were between 73.2% and 93.5%. Acetophenone and p-methylacetophenone were in high yield (92.1%, 93.5%).
Key words: chlorination acetophenone; green chemistry; solvent-free reaction
目  錄
1 緒論    1
1.1 催淚化合物的性質和用途    1
1.1.1 催淚化合物的性質    1
1.1.2 催淚化合物的制備    1
1.2 無溶劑反應的重要性    2
1.2.1 室溫下無溶劑反應的應用    2
1.2.2 加熱下無溶劑反應的應用    4
1.2.3 微波輻射下無溶劑反應的應用    5
1.3 本論文的研究意義    7
2 具有催淚活性的化合物的合成研究    8
2.1具有催淚活性的化合物的最佳條件探索    8
2.1.1 結果與討論    8 具有催淚活性的化合物的合成研究:http://www.aftnzs.live/huaxue/20190623/35085.html
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