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不同胺對合成對叔丁基苯氧基苯脒類化合物反應活性的影響

時間:2019-04-12 23:01來源:畢業論文
對叔丁基苯酚與對氯硝基苯為原料與碳酸鉀反應,生成對叔丁基苯氧基硝基苯,以鐵粉為還原劑生成對叔丁基苯氧基苯胺,再加甲酸生成甲酰胺。以甲苯,三乙胺為溶劑,三氯氧磷為脫

摘要:脒類化合物一般可用作消炎藥、抗菌素、泌尿以及心血管疾病用藥,另外的一些種類的脒類化合物則具有較好的抗癌活性。
本文以對叔丁基苯酚與對氯硝基苯為原料與碳酸鉀反應,生成對叔丁基苯氧基硝基苯,以鐵粉為還原劑生成對叔丁基苯氧基苯胺,再加甲酸生成甲酰胺。以甲苯,三乙胺為溶劑,三氯氧磷為脫水劑生成異腈,再與不同類型仲胺反應生成相應對叔丁基苯氧基苯脒類化合物。并用核磁譜圖對產物結構進行了表征。34447
以對叔丁基苯氧基苯甲酰胺與二丁胺為原料,反應生成N,N-二丁基對叔丁基苯氧基苯甲脒,最佳的反應條件為:n(對叔丁基苯氧基苯甲酰胺): n(二丁胺): n(氧化亞銅): =1:2:0.2,反應時間為4小時,反應溫度為110℃。此合成工藝比較穩定,反應條件溫和,同時對環境友好。不同胺的反應活性為:二乙胺大于二丁胺大于吲哚和二異丙胺。
畢業論文關鍵詞:對叔丁基苯氧基苯甲酰胺、二乙胺、二丁胺、異腈、合成
Effects of different amines on the synthesis of tert butyl methoxy phenyl amidine compound reaction activity
Abstract:Amidine compounds commonly used as anti-inflammatory drugs, antibiotics, urinary tract andcardiovascular drugs, some other types of amidine compounds have good anticancer activity. Used as pesticide, broad-spectrum, low toxicity, high activity of advantage.
The to tert butyl phenol and nitrobenzene chloride as raw materials and potassium carbonate reaction, generating of tert butyl benzene oxygen radical nitrobenzene, using iron powder as the reducing agent to generate the tert butyl methoxy aniline and formic acid formamide generation. In toluene, triethylamine as solvent, phosphorus oxychloride as dehydrating agent generation isocyanide, again with different types of reactions with secondary amines generated corresponding to the tert butyl methoxy phenyl amidine compounds. The structure of the product was characterized by NMR spectra.
源`自*六)維[論*文'網www.aftnzs.live

Of tert-butyl benzene oxygen radical benzamide with dibutylamine as raw material, reaction of N, N - butyl of tert butyl phenyl formamidine, the optimum reaction conditions for: n (of tert butyl benzene oxygen radical benzamide): n (Er Dingan): n (Cu2O): =1:2:0.2, reaction time is 4 hours, the reaction temperature to 110 DEG C. This synthesis process is relatively stable, mild reaction conditions, and environmental friendliness. The reaction activity of different amine ethylamine: diethylamine more than dibutylamine more than two indole and isopropylamine butylamine.
Keywords: p-tert-butyl phenoxybenzoic amides, diethylamine, dibutylamine, pyridine isocyanide, Synthesis
目錄
1.前言    1
1.1脒類化合物的簡介    1
1.2脒類化合物的研究進展    1
1.3 脒類化合物的用途    1
1.4 脒類化合物的合成方法    4
1.4.1 Pinner改進法    5
1.4.2 肟還原法    5
1.4.3 Sm/TMSCl/H2O(微量)體系法    6
1.4.4 氨基還原成脒的固相合成    6
1.4.5 催化合成脒法    7
1.4.6 鈀催化合成環狀脒    8
1.5脒類化合物的前景    9
1.6本課題研究意義及研究內容    9
1.6.1研究意義    9
1.6.2研究內容    9
1.7合成思路    10
1.7.1 合成路線    10
2.實驗部分    10
2.1實驗藥品及儀器    11
2.1.1實驗藥品    11
2.1.2實驗儀器    13
2.2實驗操作    14
2.2.1對叔丁基苯氧基硝基苯的合成制備    14
2.2.2對叔丁基苯氧基苯胺的合成制備    14 不同胺對合成對叔丁基苯氧基苯脒類化合物反應活性的影響:http://www.aftnzs.live/huaxue/20190412/31945.html
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